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Callosum Raises $10.25M Seed for Heterogeneous AI Orchestration

Callosum raised $10.25M seed led by Plural for infrastructure orchestrating AI workloads across heterogeneous chips. Brain-inspired platform challenges Nvidia's AI data center dominance with co-evolving chips and models.

Emel Kavaloglu

Feb 26, 2026

Callosum, a startup developing infrastructure for intelligent systems, has raised $10.25M in seed funding led by Plural. The platform orchestrates AI workloads across heterogeneous chips, enabling chips and AI models to co-evolve for better performance on complex problems. The capital will accelerate platform development and target AI teams tackling hard challenges alongside chip makers.

Challenging Nvidia Data Center Dominance

Callosum emerged from stealth on February 26, 2024, positioning itself to disrupt Nvidia's grip on AI data centers. Coverage highlights the startup's ambition to break this stranglehold by enabling diverse silicon architectures. Plural's lead investment signals conviction in diversifying beyond GPU monoculture, as startups seek alternatives to homogeneous compute stacks.

Homogeneous Compute Limits Complex AI

Current AI infrastructure scales via identical Nvidia GPUs, but this approach yields diminishing returns for multifaceted problems. Heterogeneous chips from various makers promise efficiency gains, yet lack unified orchestration. AI teams face fragmented tools, hindering collaboration across architectures like GPUs, TPUs, and custom ASICs.

Brain-Inspired Heterogeneous Orchestration

Named after the corpus callosum—the brain structure connecting hemispheres—Callosum applies neuroscience to AI compute. Its systems-level software dynamically allocates workloads across diverse chips. This allows AI intelligence to adapt alongside hardware, unlocking improvements in capabilities and costs unattainable with uniform scaling.

As the company's value proposition states, it moves "beyond homogeneous scaling to unlock major improvements in AI capabilities and cost for complex problems."

Hardware-Agnostic Model Collaboration

Callosum's platform enables different AI models to collaborate seamlessly across chip types, unlike vendor-locked ecosystems such as Nvidia's CUDA. Chip makers benefit by integrating their silicon into AI pipelines without custom software overhauls. This hardware-agnostic layer addresses a key market gap for next-generation AI systems.

Plural Leads Seed for Silicon Diversity

Plural led the $10.25M (≈€9.5M) round, backing Callosum's challenge to AI silicon monoculture. The European VC's investment reflects strategic validation for infrastructure enabling chip diversity. Additional backers provide the mix of mission-driven and growth capital needed to scale amid intensifying AI compute competition.

Cambridge Neuroscientists Fuel Innovation

Founded by Cambridge-trained neuroscientists, Callosum leverages deep expertise in neural connectivity for chip orchestration. This rare blend of brain science and AI infrastructure sets the team apart. Their track record in applying biological principles positions the startup to pioneer co-evolving intelligent systems.

Fragmenting AI Chip Ecosystem Emerges

The push for heterogeneous compute aligns with rising investments in diverse AI hardware. While specific competitor funding details remain sparse, Callosum joins efforts to fragment Nvidia's dominance. This shift could redefine data center economics as AI demands grow more varied.

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